Vascular sealing systems have emerged as effective tools for achieving immediate hemostasis without major complications in patients undergoing transfemoral diagnostic and interventional procedures. Two primary types of closure systems are currently available: active and passive approximators. Active approximators, which include suture-based and clip-based mechanisms, secure arteriotomy closures through the mechanical approximation of tissue margins or fixation using clips. In contrast, passive approximators utilize gel-based devices and collagen plugs to enhance hemostasis and promote coagulation.